Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis.
- Submitting institution
-
Queen Mary University of London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 618
- Type
- D - Journal article
- DOI
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10.1161/CIRCULATIONAHA.117.027844
- Title of journal
- Circulation
- Article number
- -
- First page
- 1140
- Volume
- 136
- Issue
- 12
- ISSN
- 1524-4539
- Open access status
- Compliant
- Month of publication
- July
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
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- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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14
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper was published in our top journal (Circulation, IF~23 ) as it unveiled a new mechanism to modify necrotic cores. Krams was invited for 5 lectures on basis of this work ( NGS congress, London, BHF annual meeting, London, ICS-Zurich, Switzerland, European Society, Barcelona). The PhD on this project has presented this work on conferences (the prestigious Basic Science conference of the ESC), and consequently was offered a position at Imperial College. Here she continued the work (https://wwwf.imperial.ac.uk/blog/imperial-medicine/2018/01/10/death-of-a-cell-the-vital-process-of-tidying-up-cell-debris-to-prevent-blood-clots/). The project led to ~£1000k of follow up funding (2 project grants of the BHF, and 3 PhD positions)
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -