Investigation into the potential use of poly(vinyl alcohol)/methylglyoxal fibres as antibacterial wound dressing components
- Submitting institution
-
The University of Huddersfield
- Unit of assessment
- 32 - Art and Design: History, Practice and Theory
- Output identifier
- 32
- Type
- D - Journal article
- DOI
-
10.1177/0885328214556159
- Title of journal
- Journal of Biomaterials Applications
- Article number
- -
- First page
- 1193
- Volume
- 29
- Issue
- 8
- ISSN
- 0885-3282
- Open access status
- Out of scope for open access requirements
- Month of publication
- October
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- 8 - Chemistry
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
4
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This work relates to designing chronic wound dressing using the principles of sustainable product development. As problems of antibiotic resistance increase, a continuing need for effective bioactive wound dressings is anticipated.
Methylglyoxal, an active compound in Manuka honey, was used as the biodegradable antibacterial agents. This work provides a framework for wound dressing designers to develop chronic wound dressings such as pressure ulcers and leg ulcers, using the principles of sustainability, from both the product development and from antibiotic resistance perspectives. Moreover, MGO exhibits strong activity against malignant cancer cells and can stimulate the immune response system to target tumour cells. Antiviral and antimalarial properties have also been reported. So, this platform technology could be used by designers to create many medical intervention products such as face masks compliant to EN 14683 standards. This work uses Methylglyoxal (MGO), a ketoaldehyde and a non-peroxide antimicrobial compound present in Manuka honey as the active ingredient to design antibacterial wound dressing component. The production and analysis of poly (vinyl alcohol) (PVA)/MGO fibres has never been systematically studied and this study determined the feasibility of manufacturing fibres and fabrics from mixtures of PVA and MGO, and to produce antibacterial fibres for potential use as part of a composite wound dressing material. Various analytical techniques were used in this study to characterise the novel material in details from using image analysis to characterise the fibre morphologies and by using ATR-FTIR and1H-NMR to verify the presence of MGO within the PVA/MGO fibres. Antibacterial studies were also conducted to prove the functionality of this material against E. coli and S. aureus after 24 h incubation. This research sits within the fields of technical textiles and materials science.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
