Establishing human leukemia xenograft mouse models by implanting human bone marrow-2 like scaffold-based niches
- Submitting institution
-
Queen Mary University of London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 591
- Type
- D - Journal article
- DOI
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10.1182/blood-2016-05-719021
- Title of journal
- Blood
- Article number
- -
- First page
- 2949
- Volume
- 128
- Issue
- 25
- ISSN
- 0006-4971
- Open access status
- Compliant
- Month of publication
- December
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
0
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- To understand the mechanisms that regulate self-renewal, differentiation, and transformation of human hematopoietic stem cells or evaluate the efficacy of novel treatment modalities, stem cells need to be studied in their own species-specific microenvironment. By implanting ceramic scaffolds coated with human mesenchymal stromal cells into immune-deficient mice, we were able to mimic the human bone marrow niche. The human leukemia xenograft mouse models that we have established here, in which a large cohort of patient samples successfully engrafted, will serve as an excellent resource for future studies aimed at exploring novel therapeutic approaches.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -