Modelling the glycocalyx–endothelium–erythrocyte interaction in the microcirculation: a computational study
- Submitting institution
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Sheffield Hallam University
- Unit of assessment
- 12 - Engineering
- Output identifier
- 2804
- Type
- D - Journal article
- DOI
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10.1080/10255842.2013.799146
- Title of journal
- Computer Methods in Biomechanics and Biomedical Engineering
- Article number
- -
- First page
- 351
- Volume
- 18
- Issue
- 4
- ISSN
- 1025-5842
- Open access status
- Out of scope for open access requirements
- Month of publication
- -
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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4
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This collaboration between CNR (Rome), Brunel and SHU was partially funded by Interomics (https://www.interomics.eu/) advancing the only solution to the computational challenge attending the simulation of correctly coupled flow / bio-mechanical modes of arterial wall re-modelling. Oscillatory wall shear stress (wss) and ballistic impact of suspended erythrocytes is hypothesised to provoke conformal transformations in the protective, endothelial cellular monolayer. The result is exposure of arterial wall tissues to antagonists responsible for atherosclerotic plaque initiation. The geometrical distribution of the wss signals were incorporated using an adaptive porous layer model. The work demonstrates, that continuum hemodynamics is a fiction.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -