18F‐‐tetrafluoroborate (18F‐‐TFB), a PET probe for imaging sodium‐ iodide symporter expression : Whole‐body biodistribution, safety and radiation dosimetry in thyroid cancer patients
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 97764199
- Type
- D - Journal article
- DOI
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10.2967/jnumed.117.192252
- Title of journal
- Journal of Nuclear Medicine
- Article number
- -
- First page
- 1666
- Volume
- 58
- Issue
- 10
- ISSN
- 0161-5505
- Open access status
- Not compliant
- Month of publication
- April
- Year of publication
- 2017
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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8
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- The sodium/potassium symporter (NIS) is a key molecular target in thyroid cancer imaging and therapy, and has become an important reporter gene for tracking cell-based therapies in vivo by imaging. It can be imaged with a gamma camera using gamma emitting iodine isotopes or [99mTc]pertechnetate, but high quality imaging and accurate quantification require a PET tracer. [18F]tetrafluoroborate was conceived and synthesised by the authors (DOI 10.1007/s00259-010-1523-0) for this purpose and is the first 18F-labelled NIS PET tracer. It has been adopted world-wide for use in measuring clinical outcomes in thyroid cancer therapy and in cell-based therapy trials (NCT03196518; NCT02907073; NCT03456908).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -