Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers.
- Submitting institution
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Queen Mary University of London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 699
- Type
- D - Journal article
- DOI
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10.1158/2159-8290.CD-17-0284
- Title of journal
- Cancer Discov
- Article number
- -
- First page
- 304
- Volume
- 8
- Issue
- 3
- ISSN
- 2159-8290
- Open access status
- Compliant
- Month of publication
- December
- Year of publication
- 2017
- URL
-
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- Supplementary information
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- Request cross-referral to
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- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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24
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This multidisciplinary analysis of cancer microenvironment identified a tumour-associated matrisome gene signature which correlates with tissue biomechanics and identifies patients with poor prognosis in ovarian cancer and twelve other cancers. The work led to a £2M CRUK Programme Grant (https://www.cancerresearchuk.org/funding-for-researchers/how-we-deliver-research/recently-funded-awards#Recentlyfundedawards5), project grants from CRUK (£265k, C56133/A29455) and Bowel Cancer Research (£200k), and a patent for the prognostic gene signature (EP 17821791.5, US 16/462990). The work helped two authors gain independent positions (Pearce-QMUL, Maniati-QMUL) and was highlighted in an IdeasLab video for the World Economic Forum (https://www.youtube.com/watch?v=Vz4jGjzZDGI), a stand at the Royal Society Summer Exhibition (https://royalsociety.org/science-events-and-lectures/2016/summer-science-exhibition/exhibits/deconstructing-cancer/) and in national media (https://www.theguardian.com/science/2016/jul/02/cancer-lab-grown-tumour-research-treatment).
- Author contribution statement
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- Non-English
- No
- English abstract
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