A mathematical model of subpopulation kinetics for the deconvolution of leukaemia heterogeneity
- Submitting institution
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The University of Surrey
- Unit of assessment
- 12 - Engineering
- Output identifier
- 9021062_1
- Type
- D - Journal article
- DOI
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10.1098/rsif.2015.0276
- Title of journal
- Journal of The Royal Society Interface
- Article number
- -
- First page
- 20150276
- Volume
- 12
- Issue
- 108
- ISSN
- 1742-5689
- Open access status
- Out of scope for open access requirements
- Month of publication
- -
- Year of publication
- 2015
- URL
-
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- Supplementary information
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- Request cross-referral to
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- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
-
- Research group(s)
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- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- In this work we developed and validated a novel mathematical model which captures unique cell-signatures of the cell cycle of leukaemic cells, enabling the prediction of the heterogeneity in the cancer population. Such model is important as it can help doctors predict the disease evolution and response to chemotherapy treatment, based on unique and patient-specific characteristics. Consequently, it enables a fast, low cost, accurate prediction of the optimal treatment for a specific individual. The work has received interest from the Haematology-Oncology team of the Northwick Park Hospital in London.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -