A gellan-based fluid gel carrier to enhance topical spray delivery
- Submitting institution
-
The University of Birmingham
- Unit of assessment
- 12 - Engineering
- Output identifier
- 90883976
- Type
- D - Journal article
- DOI
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10.1016/j.actbio.2019.03.036
- Title of journal
- Acta Biomaterialia
- Article number
- -
- First page
- 166
- Volume
- 89
- Issue
- -
- ISSN
- 1742-7061
- Open access status
- Compliant
- Month of publication
- March
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Emerging from funding by The Scar Free Foundation and MRC (MR/N019016/1; £2.2m), this work describes the formulation of a polysaccharide-based spray for the delivery and surface retention of fibroblasts; to prevent scar formation. This output’s findings formed the basis for a successful grant application to DEBRA (1000784, €179k; https://www.debra.org.uk/uk-funded-projects/a-novel-spray-to-treat-oral-scarring-in-eb) for the development of a mucoadhesive spray to prevent oral scarring in epidermolysis-bullosa patients and was subsequently adapted to create a nasal spray, shown to block infection with SARS-COV2 (Patent ref: 2016771.4; https://doi.org/10.1101/2020.11.18.388645). This technology attracted significant attention from media (e.g. https://news.sky.com/story/covid-19-university-of-birmingham-develops-nasal-spray-that-protects-against-coronavirus-and-prevents-transmission-12136189) and big-pharma companies are currently seeking to in-license it.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
