Acoustically modulated biomechanical stimulation for human cartilage tissue engineering
- Submitting institution
-
University of Southampton
- Unit of assessment
- 12 - Engineering
- Output identifier
- 34245236
- Type
- D - Journal article
- DOI
-
10.1039/c7lc01195d
- Title of journal
- Lab on a Chip
- Article number
- -
- First page
- 473
- Volume
- 18
- Issue
- 3
- ISSN
- 1473-0197
- Open access status
- Compliant
- Month of publication
- January
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
6
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper demonstrates a novel technique for applying mechanical stimulation to cells during acoustically levitated culture. This has importance in regenerative medicine for enhancing the production of cartilage in tissue engineering, ultimately with potential to improve the quality of life for osteoarthritis sufferers. The work led to a collaboration with doctors at Southampton General Hospital, who have used the system to produce liver cell spheroids for drug testing (paper now published in journal “Biomicrofluidics”). GlaxoSmithKline have also become interested in the possibilities for enhanced tissue models for pharma discovery and have offered £75k in-kind support for a follow-on project.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -