Sobralene, a new sex-aggregation pheromone and likely shunt metabolite of the taxadiene synthase cascade, produced by a member of the sand fly Lutzomyia longipalpis species complex
- Submitting institution
-
University of Wolverhampton
- Unit of assessment
- 12 - Engineering
- Output identifier
- 1647
- Type
- D - Journal article
- DOI
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10.1016/j.tetlet.2018.03.088
- Title of journal
- Tetrahedron Letters
- Article number
- -
- First page
- 1921
- Volume
- 59
- Issue
- 20
- ISSN
- 0040-4039
- Open access status
- Compliant
- Month of publication
- March
- Year of publication
- 2018
- URL
-
-
- Supplementary information
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https://ars.els-cdn.com/content/image/1-s2.0-S0040403918304258-mmc1.pdf
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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3
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper establishes the chemical structure of a sex pheromone of lutzomyia longipalpis (the main carrier of the parasite Leishmania infantum, the cause of the potentially fatal disease AVL), as sorbralene, a novel 6,12-membered ring-fused diterpene. The identification of a minor constituent, as the related diterpene, taxadiene raises a question about the involvement of the taxadiene synthase cascade. To our knowledge this is the first time a diterpene’s of this type has been isolated from an insect. The paper is the first in an ongoing collaboration between Hamilton (Lancaster University) and Palframan.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -