Continuous isotropic-nematic transition in amyloid fibril suspensions driven by thermophoresis
- Submitting institution
-
The University of Birmingham
- Unit of assessment
- 12 - Engineering
- Output identifier
- 42334275
- Type
- D - Journal article
- DOI
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10.1038/s41598-017-01287-1
- Title of journal
- Scientific Reports
- Article number
- 1211
- First page
- -
- Volume
- 7
- Issue
- 1
- ISSN
- 2045-2322
- Open access status
- Compliant
- Month of publication
- April
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper introduces a novel thermophoresis method to study phase transition in systems showing the behaviour of liquid crystals, specifically amyloid fibrils. Funded by ETH Zurich, the CSC, the EC (Marie Curie COFUND) and the National Research Foundation of Korea (Global Research Laboratory Program Grant, 2009-00426), it shows for the first time the continuous transition between the nematic and isotropic phases in a single microfluidic device. The characterisation of amyloid fibrils is relevant for neurodegenerative disorders, e.g. Alzheimer’s disease. The results led to a keynote lecture at ECIS2017 (http://www.ecis-web.eu/madrid2017/Programma-Madrid17.pdf) and were also presented at the UK Colloids meeting (2017).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
