Cytotoxic effect of PEI-coated magnetic nanoparticles on the regulation of cellular focal adhesions and actin stress fibres
- Submitting institution
-
University of Keele
- Unit of assessment
- 12 - Engineering
- Output identifier
- 389
- Type
- D - Journal article
- DOI
-
10.1016/j.mtla.2020.100848
- Title of journal
- Materialia
- Article number
- 100848
- First page
- -
- Volume
- 13
- Issue
- -
- ISSN
- 2589-1529
- Open access status
- Compliant
- Month of publication
- August
- Year of publication
- 2020
- URL
-
https://www.sciencedirect.com/science/article/pii/S2589152920302647
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This work formed a major component of a PhD project within the EU-FP7 ITN “MagneticFUN” resulting in a successful thesis defence. Whilst many studies have explored the toxicity of different types of nanoparticles via end-stage observations (i.e. cell viability), few have focused on the effect nanoparticles and their coatings have directly on the cell stresses that mediate cell death. In this paper, changes to cell morphology, adhesion, and gene expression, were found to be correlated to magnetic nanoparticle doses, which is important to understand biocompatibility in the design of future nanoparticles for a range of biomedical applications including gene therapy.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
