Annexin-enriched osteoblast-derived vesicles act as an extracellular site of mineral nucleation within developing stem cell cultures
- Submitting institution
-
The University of Birmingham
- Unit of assessment
- 12 - Engineering
- Output identifier
- 52447423
- Type
- D - Journal article
- DOI
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10.1038/s41598-017-13027-6
- Title of journal
- Scientific Reports
- Article number
- 12639
- First page
- -
- Volume
- 7
- Issue
- -
- ISSN
- 2045-2322
- Open access status
- Compliant
- Month of publication
- October
- Year of publication
- 2017
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
6
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Extracellular vesicles are biological nanoparticles known to be involved in cell-cell communication. This work demonstrates the ability to manufacture such vesicles with increased levels of annexin proteins. These nanoparticles were shown to enhance the amount and maturity of minerals produced by stem cells when compared with BMP2; the active protein used in an established spinal fusion product (INFUSE, Medtronic). These findings have led to a patent (WO2018/115871), an invited talk at the European Orthopaedics Society conference 2018, media coverage (https://www.innovatorsmag.com/regenerative-tools-inspired-by-nature/, https://medicalxpress.com/news/2017-10-method-tissue-regeneration-nature-scientists.html, https://futurism.com/scientists-have-uncovered-a-way-to-regenerate-human-bone-and-tissue/), an innovation award at the Enterprising Birmingham competition 2017, and £85,000 in funding (MC_PC_15032).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
