Reprogramming roadmap reveals route to human induced trophoblast stem cells
- Submitting institution
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University of Southampton
- Unit of assessment
- 5 - Biological Sciences
- Output identifier
- 59809884
- Type
- D - Journal article
- DOI
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10.1038/s41586-020-2734-6
- Title of journal
- Nature
- Article number
- -
- First page
- 101
- Volume
- 586
- Issue
- 7827
- ISSN
- 0028-0836
- Open access status
- Exception within 3 months of publication
- Month of publication
- September
- Year of publication
- 2020
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
38
- Research group(s)
-
-
- Citation count
- 8
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- Rackham - I am a corresponding author of this study in which I designed, coordinated and implemented all of the single-cell RNAseq aspects of the work. We were able to identify that the trophectoderm transcriptional program was activated during reprogramming and that a small population of cells were entering a trophoblast stem cell state. We used this observation to create induced trophoblast stem cells directly reprogrammed from fibroblasts for the first time.
- Non-English
- No
- English abstract
- -
