The landscape of viral associations in human cancers
- Submitting institution
-
The University of East Anglia
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 182585975
- Type
- D - Journal article
- DOI
-
10.1038/s41588-019-0558-9
- Title of journal
- Nature Genetics
- Article number
- -
- First page
- 320
- Volume
- 52
- Issue
- 3
- ISSN
- 1061-4036
- Open access status
- Compliant
- Month of publication
- March
- Year of publication
- 2020
- URL
-
http://www.scopus.com/inward/record.url?scp=85079063026&partnerID=8YFLogxK
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
12
- Research group(s)
-
-
- Citation count
- 31
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This work presents the first comprehensive study of which viruses are found in a large variety of cancers, by analysing whole genome sequencing data. Three analysis pipelines were used in a consensus-based approach to detect and quantify the amount of virus including SEPATH developed by Brewer. SEPATH has been further developed and is opensource and been containerized (https://github.com/UEA-Cancer-Genetics-Lab/sepath_tool_UEA). Identifying new links between infection and cancer types has the potential to provide vaccines, such as the HPV vaccine, which could reduce the global impact of cancer. This work has led to a successful grant application from Prostate Cancer UK (MA-ETNA19-003; £77,925).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -