Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 97488989
- Type
- D - Journal article
- DOI
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10.1093/europace/eut349
- Title of journal
- EUROPACE
- Article number
- -
- First page
- 416
- Volume
- 16
- Issue
- 3
- ISSN
- 1099-5129
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
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- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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4
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Many anti-arrhythmic drugs used to treat atrial fibrillation (AF) have dangerous side effects. We applied highly detailed biophysical models of the pulmonary veins (known sites of AF arrhythmogenesis) to test the drug efficacy and safety. We for the first time demonstrated the advantage of using multi-channel over single-channel blockers. Results were evaluated using a range of drugs from each category. The work has been cited as a milestone in the fields of clinical application of cardiac models (DOI: 10.1113/JP271404) and pharmacology (DOI: 10.1517/14728222.2016.1159300), and led to a BHF project (PG/15/8/31130).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -