Self-assembled monolayers of alendronate on Ti6Al4V alloy surfaces enhance osteogenesis in mesenchymal stem cells
- Submitting institution
-
University of Ulster
- Unit of assessment
- 12 - Engineering
- Output identifier
- 76491028
- Type
- D - Journal article
- DOI
-
10.1038/srep30548
- Title of journal
- Scientific Reports
- Article number
- 30548
- First page
- -
- Volume
- 6
- Issue
- 30548
- ISSN
- 2045-2322
- Open access status
- Compliant
- Month of publication
- July
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
4
- Research group(s)
-
C - Biomaterials and Tissue Engineering
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This collaborative paper combines internationally leading multidisciplinary expertise to develop smart bioactive substrate surfaces without the need for expensive (commonly vacuum-based) fabrication processes. The novel work reports for the first time the conditions required to deposit a self-assembled monolayer (SAM) carrying an active drug used for the treatment of osteoporosis (a condition in which causes an increased likelihood of a bone fractures in those affected). The Ulster contribution to the work was funded from an EPSRC Grand Challenge Award (EP/C534247/1) - “Regenerative Medicine – A New Industry (Remedi)” (Core collaborators: Universities of Loughborough, Nottingham, Ulster, Cambridge, Birmingham, and Liverpool).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -