Patient-Maintained Propofol Sedation
- Submitting institution
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Nottingham Trent University
- Unit of assessment
- 32 - Art and Design: History, Practice and Theory
- Output identifier
- 40 - 1379108
- Type
- T - Other
- DOI
-
-
- Location
- -
- Brief description of type
- N/A
- Open access status
- Out of scope for open access requirements
- Month
- April
- Year
- 2018
- URL
-
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- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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4
- Research group(s)
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D - Product Innovation Centre
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Each year, many operations in the UK are performed with the patient awake, without the use of general anaesthesia. These include joint replacement procedures, and in order to reduce patient anxiety, the supervising anaesthetist delivers the sedative propofol intravenously using a target-controlled infusion (TCI) device. However, it is clinically challenging to judge the required effect-site concentration of sedative for an individual patient, resulting in patient care issues related to over or under-sedation.
To improve the process by allowing the patient to request an increase in sedation, Breedon developed a patient-maintained propofol sedation (PMPS) system, with a hand-held button and an intuitive anaesthetist user interface.
Anaesthetists from Nottingham University Hospitals NHS were asked to evaluate both a new PMPS interface prototype along with an existing infusion pump interface and patients who have had experience of ‘awake’ operations and sedation took part in a participatory design process for the patient button.
To evaluate the system, NTU applied for Medicines and Healthcare Products Regulatory Agency (MHRA) approval and a full NHS clinical trial with 80 patients was designed and undertaken. This tested the validity of a PMPS system to improve patient experience and patient care outcomes. The clinical trial resulted in a positive and very encouraging outcome with patients overall having 40 percent less of the propofol drug when compared to anaesthetist control.
The research has been in collaboration with B.Braun, a major sedation pump supplier. Discussions are ongoing with the company and it is envisaged that next generation of pump technology will have ‘patient-maintained sedation’ functionality embedded in the design.
The research has been disseminated via three academic journal articles conference papers and via specialist media.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -