Decoupling competing surface binding kinetics and reconfiguration of receptor footprint for ultrasensitive stress assays
- Submitting institution
-
University of York
- Unit of assessment
- 12 - Engineering
- Output identifier
- 65600331
- Type
- D - Journal article
- DOI
-
10.1038/nnano.2015.174
- Title of journal
- Nature Nanotechnology
- Article number
- -
- First page
- 899
- Volume
- 10
- Issue
- 10
- ISSN
- 1748-3387
- Open access status
- Out of scope for open access requirements
- Month of publication
- August
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
7
- Research group(s)
-
B - Intelligent Systems and Nano-Science
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This work presents label free quantitative detection of biomarkers for HIV and Haemophilia down to femtomolar (fM) levels. It demonstrates the limits of surface plasmon resonance (current commercial gold standard) compared to nano-mechanical sensing. The work received significant attention from clinicians in the UK and Italy for Haemophilia-A detection (Contact: Consultant Physicians, UK and Italy), resulting in seed funding (£40k) from BioVIIIx, Naples (Contact: Senior Researcher, BioVIIIx) for the start-up 3P-Sense (Company no 1006254) to commercialise this technology.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -