A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration.
- Submitting institution
-
University College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 12173
- Type
- D - Journal article
- DOI
-
10.1016/j.bpj.2016.08.011
- Title of journal
- Biophysical journal
- Article number
- -
- First page
- 1541
- Volume
- 111
- Issue
- 7
- ISSN
- 0006-3495
- Open access status
- Not compliant
- Month of publication
- October
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
https://www.cell.com/cms/10.1016/j.bpj.2016.08.011/attachment/ac34f1ba-f06a-4ce0-ab46-8d1b7674f7c5/mmc1.pdf
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
9
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This research is a result of a close intercontinental collaboration with world-leading researchers in the field of mechanobiology (mostly American institutions: Massachusetts Institute of Technology, University of Pennsylvania and Cornell University). A mechanistic theoretical/ computational framework was developed predicting nuclear deformation during cancer cell passing through the vessel wall. This research was a result of Wellcome Trust Fellowship to UCL team, led to the establishment of a high-quality international network and so far, attracted significant attention as indicated by a high number of citations. UCL as a lead secured multiple funding, including a recent BBSRC investigator grant (£300K).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -