A Dinuclear Ruthenium(II) Complex Excited by Near-Infrared Light through Two-Photon Absorption Induces Phototoxicity Deep within Hypoxic Regions of Melanoma Cancer Spheroids
- Submitting institution
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The University of Sheffield
- Unit of assessment
- 12 - Engineering
- Output identifier
- 7072
- Type
- D - Journal article
- DOI
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10.1021/jacs.9b11313
- Title of journal
- Journal of the American Chemical Society
- Article number
- -
- First page
- 4639
- Volume
- 142
- Issue
- 10
- ISSN
- 0002-7863
- Open access status
- Compliant
- Month of publication
- February
- Year of publication
- 2020
- URL
-
-
- Supplementary information
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- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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7
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- The study reports on a novel photodynamic therapy (PDT) using a dinuclear ruthenium Ru(II) photo-oxidising compound synthesised in our lab. Ru(II) was readily uptaken by human melanoma tumour spheroids, binding specifically to DNA. When irradiated by a 2-photon (2Ph) infrared laser, DNA photo-oxidation arose without oxygen radicals, that normally afford cancer cell resistance. Significance was demonstrated showing rapid melanoma cell death of tumours, including hypoxic regions. Impact is in future technology development of Ru(II)-2Ph-NIR as a highly specific photodynamic therapy for melanoma, targeted accurately using 2Ph laser with micron precision.
- Author contribution statement
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- Non-English
- No
- English abstract
- -