Fast quantitative MRI using Controlled Saturation Magnetization Transfer
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 101706908
- Type
- D - Journal article
- DOI
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10.1002/mrm.27442
- Title of journal
- Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
- Article number
- -
- First page
- 907
- Volume
- 81
- Issue
- 2
- ISSN
- 1522-2594
- Open access status
- Compliant
- Month of publication
- September
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
2
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Quantitative MRI can provide objective measurements of tissue properties, to aid precision of diagnosis. A fundamental problem however is a current inability to produce consistent tissue relaxation parameter measurements at different scanning centres and/or in different studies. This paper, among the most downloaded papers in 2018-19 (https://blog.ismrm.org/2020/06/23/top-downloaded-mrm-articles-from-2018-and-2019/), demonstrates clearly that a major cause is strong interaction between protons in water (source of the MRI signal) and proteins (usually not considered). A key innovation was a modification to the scanning method that greatly improves reproducibility and stability. The method has been patented (WO2018185496A2) and recently proven by cross-vendor multi-site evaluation (10.1002/mrm.28109).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -