Application of hot melt extrusion for improving bioavailability of artemisinin a thermolabile drug
- Submitting institution
-
The University of Bradford
- Unit of assessment
- 12 - Engineering
- Output identifier
- 62
- Type
- D - Journal article
- DOI
-
10.1080/03639045.2017.1386200
- Title of journal
- Drug Development and Industrial Pharmacy
- Article number
- -
- First page
- 206
- Volume
- 44
- Issue
- 2
- ISSN
- 0363-9045
- Open access status
- Compliant
- Month of publication
- -
- Year of publication
- 2017
- URL
-
https://www.tandfonline.com/doi/abs/10.1080/03639045.2017.1386200?journalCode=iddi20
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Artemisinin is an important World Health Organisation drug used in the treatment of malaria. This paper describes successful UK-India collaborative research undertaken to develop a low cost way of improving the drug’s performance (solubility), performed as part of a cross-disciplinary PhD project. It represents the first published study of a hot melt extruded formulation of artemisinin, due to its highly thermally sensitive nature. This which was made possible by using of a newly marketed polymer. Drug release was quantified in laboratory and animal studies and found to be significantly improved over the standard crystal form of the drug.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
