Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets
- Submitting institution
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The University of East Anglia
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 182585611
- Type
- D - Journal article
- DOI
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10.1038/s41588-018-0086-z
- Title of journal
- Nature Genetics
- Article number
- -
- First page
- 682
- Volume
- 50
- Issue
- -
- ISSN
- 1061-4036
- Open access status
- Compliant
- Month of publication
- April
- Year of publication
- 2018
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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85
- Research group(s)
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-
- Citation count
- 83
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This study identified a large number of genetic changes that underlie the development and spread of prostate cancer using cutting-edge bioinformatics techniques (variant calling, clonal evolution, mutational process detection) and used in silico techniques to identify potential drug targets. Brewer was a senior author on this work, chair of the CRUK-ICGC prostate group bioinformatics committee and contributed to the analysis. This work has opened up many potential ways of targeting the disease e.g. research is underway into the BRAF and ATM proteins. It also helped secure funding for an expansion of this work to an international consortium (CRUK C5047/A29626; £1.3M).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -