High-voltage 10 ns delayed paired or bipolar pulses for in vitro bioelectric experiments
- Submitting institution
-
Bangor University / Prifysgol Bangor
- Unit of assessment
- 12 - Engineering
- Output identifier
- UoA12_30
- Type
- D - Journal article
- DOI
-
10.1016/j.bioelechem.2020.107648
- Title of journal
- Bioelectrochemistry
- Article number
- 107648
- First page
- -
- Volume
- 137
- Issue
- -
- ISSN
- 1567-5394
- Open access status
- Compliant
- Month of publication
- September
- Year of publication
- 2020
- URL
-
-
- Supplementary information
-
https://ars.els-cdn.com/content/image/1-s2.0-S1567539420302061-mmc1.xml
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
4
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- The bioelectric effect of nanosecond pulse electric fields can be cancelled through delivery of pulses with alternate polarity (bipolar cancellation). For the first time, bipolar cancellation is studied for brain cancer cells and bipolar pulse delays in the nanosecond range demonstrating that cancellation loses efficiency for delays below 100 nanoseconds. This challenges all available bioelectric models of bipolar cancellation, opens new avenues for cell characterization, and shows the possibility to combine multiple waveforms for neurostimulation and cancer medicine applications. This work enhances an array of novel approaches for brain cancer cell electrostimulation developed within the successful SUMCASTEC project (www.sumcastec.eu).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
