Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion
- Submitting institution
-
King's College London
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 111166730
- Type
- D - Journal article
- DOI
-
10.7554/eLife.12167
- Title of journal
- eLife
- Article number
- e12167
- First page
- -
- Volume
- 5
- Issue
- APRIL2016
- ISSN
- 2050-084X
- Open access status
- Compliant
- Month of publication
- April
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
8
- Research group(s)
-
-
- Citation count
- 58
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Culmination of 8 years of research on refining and validating computational models with in vivo experiments. Emergent oscillations observed in the agent-based models led to discovery of real oscillations in vivo, providing the first dynamics-based mechanism explaining expanded tumour/retinopathy vessels. This paper is the foundation of Bentley’s temporal basis theory (Bentley, Philosophical Trans 2017) identifying dynamics as a new therapeutic target. The theory, evidenced here, directly generated significant funding ($1.1M - BIDMC Harvard Medical School 2013, $250K NIH 2015, £2M Crick 2018). Keynotes, e.g. IEEE ALife 2013 and 2016, and invited talks, e.g. GRC Angiogenesis 2015; Cincinnatti Childrens Hospital 2020.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
