Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology: Vascular impairments in HD
- Submitting institution
-
University of Nottingham, The
- Unit of assessment
- 9 - Physics
- Output identifier
- 3842684
- Type
- D - Journal article
- DOI
-
10.1002/ana.24406
- Title of journal
- Annals of Neurology
- Article number
- -
- First page
- 160
- Volume
- 78
- Issue
- 2
- ISSN
- 0364-5134
- Open access status
- Out of scope for open access requirements
- Month of publication
- April
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
15
- Research group(s)
-
F - Sir Peter Mansfield Imaging Group
- Citation count
- 107
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- Professor Francis designed, acquired, analysed and interpreted the 7T human magnetic resonance imaging (MRI) experiments which form a key component of this paper. She also developed and programmed the Look-Locker echo-planar imaging (LL-EPI) MRI pulse sequence for the assessment of arterial cerebral blood volume (aCBV) in the human brain. In addition, she performed simulations and developed the two-compartment vascular kinetic model to analyse the data and from which to compute aCBV maps. This led to the key finding of a significant increase in aCBV in cortical grey matter in the Huntington’s Disease cohort compared to control subjects.
- Non-English
- No
- English abstract
- -
