Activated Polyhydroxyalkanoate Meshes Prevent Bacterial Adhesion and Biofilm Development in Regenerative Medicine Applications
- Submitting institution
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The University of Sheffield
- Unit of assessment
- 12 - Engineering
- Output identifier
- 7818
- Type
- D - Journal article
- DOI
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10.3389/fbioe.2020.00442
- Title of journal
- Frontiers in Bioengineering and Biotechnology
- Article number
- 442
- First page
- -
- Volume
- 8
- Issue
- -
- ISSN
- 2296-4185
- Open access status
- Compliant
- Month of publication
- May
- Year of publication
- 2020
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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7
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Novel, activated antibacterial polyhydroxyalkanaote meshes, uniquely functionalised with amhelin, an antimicrobial peptide, and Dispersin B, an antibiofilm enzyme, were developed for regenerative medicine applications. Such materials are crucial for successful tissue regeneration without the risking surgery-linked infections. These were produced by electrospinning using unique amphiphilic star-shaped macromolecules, resulting in a one-step functionalisation of the fibres. The meshes were rigorously characterised using contact angle measurement, SEM, antibacterial/antibiofilm activity and biocompatibility with mouse fibroblasts. This work resulted in extensive collaboration with a clinician in Bochum, Germany and NPL and also attracted industrial interest from Biersdorf, Germany and Jaguar, UK.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -