GADD45β Loss Ablates Innate Immunosuppression in Cancer
- Submitting institution
-
Coventry University
- Unit of assessment
- 3 - Allied Health Professions, Dentistry, Nursing and Pharmacy
- Output identifier
- 31555094
- Type
- D - Journal article
- DOI
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10.1158/0008-5472.CAN-17-1833
- Title of journal
- Cancer Research
- Article number
- -
- First page
- 1275
- Volume
- 78
- Issue
- 5
- ISSN
- 1538-7445
- Open access status
- Technical exception
- Month of publication
- December
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
19
- Research group(s)
-
-
- Citation count
- 11
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- I am a co-first author on this publication and was the pivotal publication of my post-doctoral studies at Imperial College London in which I identified an innate-immunity “checkpoint” in macrophages, mediated by the NF-κB-regulated protein GADD45β, that blocks tumour microenvironment (TME)-based inflammation, pro-inflammatory tumour associated macrophage (TAM) activation and T-cell trafficking into tumours. I was involved in this project during initial conceptualization meetings through to publication. I was responsible for designing, performing all experiments and ultimately analysing all of the data in preparation for publication. I produced all of the figures, wrote up the manuscript and responded to reviews comments.
- Non-English
- No
- English abstract
- -