1H NMR-Linked Urinary Metabolic Profiling of Niemann-Pick Class C1 (NPC1) Disease: Identification of Potential New Biomarkers using Correlated Component Regression (CCR) and Genetic Algorithm (GA) Analysis Strategies
- Submitting institution
-
De Montfort University
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 11048
- Type
- D - Journal article
- DOI
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10.2174/2213235X02666141112215616
- Title of journal
- Current Metabolomics
- Article number
- -
- First page
- 88
- Volume
- 2
- Issue
- 2
- ISSN
- 2213-235X
- Open access status
- Out of scope for open access requirements
- Month of publication
- -
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
12
- Research group(s)
-
-
- Citation count
- 9
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Niemann-Pick Class 1 (NPC1) disease is a rare, debilitating neurodegenerative lysosomal storage disease; we employed high-resolution 1H NMR analysis coupled to discern differences between the urinary metabolic profiles of 13 untreated NPC1 disease and 47 heterozygous (parental) carrier control participants.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
