Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging
- Submitting institution
-
King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 97764470
- Type
- D - Journal article
- DOI
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10.1016/j.biomaterials.2014.04.004
- Title of journal
- Biomaterials
- Article number
- N/A
- First page
- 5840
- Volume
- 35
- Issue
- 22
- ISSN
- 0142-9612
- Open access status
- Out of scope for open access requirements
- Month of publication
- April
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
15
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Combined PET/MRI could improve sentinel lymph node (SLN) imaging by enabling, for the first time, not only SLN detection (PET) but also imaging their tumour content presurgically (MRI), reducing morbidity due to unnecessary SLN removals. This paper describes the first superparamagnetic magnetic iron oxide nanoparticles (SPIO) coated with aluminium hydroxide, imparting water solubility and exceptionally efficient, simple radiolabelling with common positron emitters, and hence detection by both PET and MRI. The exceptional radioactivity loading underpinned a >£5m EPSRC programme grant (EP/R045046/1) for in vivo positron emitting particle tracking (PEPT) to visualise fluid mechanics via a single particle in real time.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
