Potassium channel dysfunction in human neuronal models of Angelman syndrome
- Submitting institution
-
University of Southampton
- Unit of assessment
- 5 - Biological Sciences
- Output identifier
- 59809880
- Type
- D - Journal article
- DOI
-
10.1126/science.aav5386
- Title of journal
- Science
- Article number
- -
- First page
- 1486
- Volume
- 366
- Issue
- 6472
- ISSN
- 0036-8075
- Open access status
- Deposit exception
- Month of publication
- December
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
http://science.sciencemag.org/content/366/6472/1486/suppl/DC1
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
24
- Research group(s)
-
-
- Citation count
- 22
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- Rackham - I am a contributing author to this study. My group carried out all of the RNA-seq work that was involved in understanding the transcriptional consequences of a Angelman syndrome mutation. Our results confirmed that the main effect of this mutation is to the physical properties of a receptor, the transcriptional changes are limited.
- Non-English
- No
- English abstract
- -