Fetal whole heart blood flow imaging using 4D cine MRI
- Submitting institution
-
King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 136868000
- Type
- D - Journal article
- DOI
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10.1038/s41467-020-18790-1
- Title of journal
- Nature Communications
- Article number
- 4992
- First page
- -
- Volume
- 11
- Issue
- 1
- ISSN
- 2041-1723
- Open access status
- Compliant
- Month of publication
- October
- Year of publication
- 2020
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
15
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Ultrasound (Echo) is the standard imaging modality used to assess fetal cardiovascular anomalies, but 3D imaging is circumscribed. Magnetic resonance (MR) imaging is emerging as a modality for fetal cardiology, but hitherto has largely been limited to 2D slices, especially for flow quantification. The paper achieves, for the first time, full 4D (3D space + cardiac phase) MR imaging of the whole heart and great vessels for both anatomy and vector flow of blood, validated in-vivo. Full correction for fetal motion ensures robust performance. The method is already deployed in a commissioned NHS service (weekly clinics) at St. Thomas' Hospital.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -