A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns
- Submitting institution
-
Queen Mary University of London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 2595
- Type
- D - Journal article
- DOI
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10.1016/j.biomaterials.2018.10.014
- Title of journal
- Biomaterials
- Article number
- -
- First page
- 63
- Volume
- 190-191
- Issue
- -
- ISSN
- 0142-9612
- Open access status
- Compliant
- Month of publication
- January
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
10
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- We developed a new model of the tumour microenvironment combining biomimetic hydrogels with 3D-printed scaffolds to co-culture ovarian cancer with mesothelial cells. These 3D co-cultures permit the physical or enzymatic separation of individual cell populations for multi-level analyses and intraperitoneal xenografts, requiring fewer cells in a targeted approach compared to standard methods. Upon transcriptome-wide and protein expression analyses and clinical validation using patient-derived cells, we identified several targets that can be pursued therapeutically to interfere with cancer cell growth and cancer-promoting factors. I conceptualized and designed all experiments. I performed experiments and data analyses. I wrote and reviewed the manuscript.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -