An ultra scale-down methodology to characterize aspects of the response of human cells to processing by membrane separation operations.
- Submitting institution
-
University College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 12216
- Type
- D - Journal article
- DOI
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10.1002/bit.26257
- Title of journal
- Biotechnol Bioeng
- Article number
- -
- First page
- 1241
- Volume
- 114
- Issue
- 6
- ISSN
- 1097-0290
- Open access status
- Compliant
- Month of publication
- February
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
3
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This fundamental understanding of how process engineering conditions affect bioprocessing was the subject of prize-winning presentations in top ECI-meetings in cell therapy, and at bioProcessUK and IChemE with the lead two authors going onto careers at Sartorius and Immunocore. This and related studies were key to the establishment of the £2.7m Pall-UCL Centre of Excellence programme which includes the controlled bioprocessing of delicate cell hosts for example fundamental to the full-scale development of new classes of vaccines. Also, the defined membrane processing achieved led to a £214k EPSRC-Merck EngD award for controlled antibody formulation now successfully published (https://doi.org/10.1002/bit.26859; https://doi.org/10.1016/j.memsci.2019.117606).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -