Degradation mechanisms of bioresorbable polyesters. Part 1. Effects of random scission, end scission and autocatalysis
- Submitting institution
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The University of Leicester
- Unit of assessment
- 12 - Engineering
- Output identifier
- 1474
- Type
- D - Journal article
- DOI
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10.1016/j.actbio.2013.12.039
- Title of journal
- Acta Biomaterialia
- Article number
- -
- First page
- 2223
- Volume
- 10
- Issue
- 5
- ISSN
- 1742-7061
- Open access status
- Out of scope for open access requirements
- Month of publication
- May
- Year of publication
- 2014
- URL
-
-
- Supplementary information
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https://doi.org/10.1016/j.actbio.2013.12.039
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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3
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Polylactic and polyglycolic acids are the most common biodegradable polymers used in medical implants. It was widely claimed that their degradation is by random scission but this paper shows that the claim is misleading. Experimental data from 31 papers were examined using our mathematical model that relates the data back to the underlying degradation mechanism. We found that both random and end scissions have to be active in order for the data to be explained. The paper led to a change in understanding and it is included in influential and highly-cited reviews (e.g. Malikmammadov 2018 Journal Biomaterials Science FWCI 19.01).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -