A novel chemo–mechano–biological model of arterial tissue growth and remodelling
- Submitting institution
-
University of Oxford
- Unit of assessment
- 12 - Engineering
- Output identifier
- 9447
- Type
- D - Journal article
- DOI
-
10.1016/j.jbiomech.2016.04.037
- Title of journal
- Journal of Biomechanics
- Article number
- -
- First page
- 2321
- Volume
- 49
- Issue
- 12
- ISSN
- 0021-9290
- Open access status
- Compliant
- Month of publication
- May
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
https://ars.els-cdn.com/content/image/1-s2.0-S0021929016305425-mmc1.pdf
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
2
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Predicting aneurysm stabilisation or growth is a key research goal for this common and potentially fatal condition. The developed predictive framework is the first ever to couple reaction diffusion of species in the blood vessel wall with solid-fluid interaction effects of pulsatile blood flow. The mechanistic model successfully predicted in silico the outcome of in vivo trial of anti-TGF-beta for aneurysm stabilisation, paving the way for supporting applications for in human trials.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -