Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization.
- Submitting institution
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University of Oxford
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 1936
- Type
- D - Journal article
- DOI
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10.1098/rsif.2014.0352
- Title of journal
- Journal of the Royal Society, Interface
- Article number
- ARTN 20140352
- First page
- 20140352
- Volume
- 11
- Issue
- 97
- ISSN
- 1742-5689
- Open access status
- Out of scope for open access requirements
- Month of publication
- August
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
4
- Research group(s)
-
-
- Citation count
- 106
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper introduces the novel use of fractional calculus for the description of complex biological tissues, elucidating the role of tissue microstructure with respect to formerly un-related attributes of cardiac conduction. The work has >15000 direct downloads and is recommended on research highlight platforms (e.g. https://f1000.com/prime/718508462). It has motivated experimental studies demonstrating fractional scaling laws of cardiac dynamics, thus corroborating model predictions (https://doi.org/10.1103/PhysRevE.100.020201), and inspired the development of further nonlinear models of biological tissues and processes, both for investigations of cardiac function (e.g. https://doi.org/10.3389/fphys.2018.00975, https://doi.org/10.1063/1.4999610) and in other fields of biology (gliar scars, neuroinflammation, wound healing, and fibrosis disease).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -