Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides
- Submitting institution
-
University of Keele
- Unit of assessment
- 12 - Engineering
- Output identifier
- 407
- Type
- D - Journal article
- DOI
-
10.1073/pnas.1518634113
- Title of journal
- Proceedings of the National Academy of Sciences
- Article number
- -
- First page
- E291
- Volume
- 113
- Issue
- 3
- ISSN
- 0027-8424
- Open access status
- Out of scope for open access requirements
- Month of publication
- January
- Year of publication
- 2016
- URL
-
https://www.pnas.org/content/113/3/E291
- Supplementary information
-
10.1073/pnas.1704696114
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
8
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Originating from a BBSRC-funded Lola grant, this collaborative study developed a new cell penetrating peptide platform (Glycosaminoglycan-binding enhanced transduction; GET) for use in targeting cells in vitro and in vivo. The work formed part of an EPSRC CDT in Regenerative Medicine (co-PI: El Haj); supported the career development of Dixon towards a prestigious Chancellor's Fellowship; and led to a PhD studentship (Markides) and a BBSRC-funded PhD studentship (Rotherham). The GET platform has been patented (EP3082871B1; https://data.epo.org/publication-server/rest/v1.0/publication-dates/20190501/patents/EP3082871NWB1/document.pdf) and is now being translated commercially and clinically (contact: james.dixon@nottingham.ac.uk).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
