Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota
- Submitting institution
-
The University of Bradford
- Unit of assessment
- 3 - Allied Health Professions, Dentistry, Nursing and Pharmacy
- Output identifier
- 121
- Type
- D - Journal article
- DOI
-
10.1002/ijc.28853
- Title of journal
- International Journal of Cancer
- Article number
- -
- First page
- 2004
- Volume
- 135
- Issue
- 9
- ISSN
- 0020-7136
- Open access status
- Out of scope for open access requirements
- Month of publication
- -
- Year of publication
- 2014
- URL
-
https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.28853
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
21
- Research group(s)
-
-
- Citation count
- 50
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- PL created key project data. More specifically 11a-hydroxy-9, 15-dioxo-2, 3, 4, 5-tetranor-prostane-1, 20-dioic acid (known as PGE-M) is a stable metabolite of PGE2. Analytical methodology for PGE-M (and urinary creatinine) using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed in Bradford and urine samples analysed. This analysis contributed to the finding that EPA-FFA leads to conversion to DPA and DHA, reduction of PGE-M excretion (indicating reduced systemic PGE2 production) and reduced systemic but not colonic inflammation (fig 4).
PL also drafted the relevant results section, contributed to data analysis and writing the manuscript and undertook critical revision of the final manuscript.
- Non-English
- No
- English abstract
- -
