Estimation of Cardiovascular Relative Pressure Using Virtual Work-Energy
- Submitting institution
-
King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 113341341
- Type
- D - Journal article
- DOI
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10.1038/s41598-018-37714-0
- Title of journal
- Scientific Reports
- Article number
- 1375
- First page
- -
- Volume
- 9
- Issue
- 1
- ISSN
- 2045-2322
- Open access status
- Compliant
- Month of publication
- February
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
12
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Clinical decisions for many cardiovascular interventions rely on the measurement of blood pressure drops. Current gold standard catheter assessment is invasive while noninvasive echo measures have limited accuracy. This paper presents a novel noninvasive assessment method using phase contrast magnetic resonance imaging coupled with a physics-based postprocessing algorithm, and presents verification (in-silico testing) and validation (in-vivo patient testing). This is the first noninvasive measure proven to estimate transient drops in pressure in vivo and is currently being tested in the brain and heart, is patented (16085258) and has led to follow-on funding to demonstrate clinical efficacy (BHF TG/17/3/33406).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -