Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization.
- Submitting institution
-
Queen Mary University of London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 2588
- Type
- D - Journal article
- DOI
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10.1073/pnas.1608763114
- Title of journal
- Proc Natl Acad Sci U S A
- Article number
- -
- First page
- 2395
- Volume
- 114
- Issue
- 9
- ISSN
- 1091-6490
- Open access status
- Compliant
- Month of publication
- February
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
6
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This work represents one of the outcomes of MRC research grant “Gene therapy for refractory epilepsy” (MR/L01095X/1, £2,468,065). Here we established the first ever simultaneous recording from neuronal soma using conventional micropipette and submicron synapses belonging to the same hippocampal neuron using scanning nanopipette. The work helped securing follow up MRC funding (MR/R015333/1) "Engineered Potassium Channel gene therapy for epilepsy" (£1,985,616 )
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -