Contaminants in commercial preparations of ‘purified’ small leucine-rich proteoglycans may distort mechanistic studies
- Submitting institution
-
University of Keele
- Unit of assessment
- 12 - Engineering
- Output identifier
- 388
- Type
- D - Journal article
- DOI
-
10.1042/BSR20160465
- Title of journal
- Bioscience Reports
- Article number
- BSR20160465
- First page
- -
- Volume
- 37
- Issue
- 1
- ISSN
- 0144-8463
- Open access status
- Compliant
- Month of publication
- January
- Year of publication
- 2017
- URL
-
https://portlandpress.com/bioscirep/article/37/1/BSR20160465/56586/Contaminants-in-commercial-preparations-of
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
6
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- It was discovered in this study that widely used “purified” commercial preparations of decorin and biglycan were contaminated with other proteins. This project was led by Keele in collaboration with Cardiff and St Andrews Universities with funding support from Genodisc (HEALTH-F2-2008-20162) and the Orthopaedic Institute Ltd (RPG 135). This study was accompanied by a commentary in Nature (https://doi.org/10.1038/496300c), was presented at the British Society for Matrix Biology Meeting (2017) and was the subject of an independent Bioscience Reports commentary (https://doi.org/10.1042/BSR20170078).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
