Cardiomyocytes sense matrix rigidity through a combination of muscle and non-muscle myosin contractions
- Submitting institution
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Queen Mary University of London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 614
- Type
- D - Journal article
- DOI
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10.1016/j.devcel.2017.12.024
- Title of journal
- Developmental Cell
- Article number
- -
- First page
- 326
- Volume
- 44
- Issue
- 3
- ISSN
- 1534-5807
- Open access status
- Compliant
- Month of publication
- January
- Year of publication
- 2018
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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12
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Here we identified a novel cardiomyocyte specific rigidity sensing mechanism. Led to a successful BBSRC grant BB/S001123/1; Contributed to faculty position for TI (QMUL, 2017) and PhD studentship for PP as well as successful PhD completion for WH. Invitations to speak at institutional seminars (Kent, Glasgow, Birmingham, Innsbruck); invited conference talks (https://cvrc.wisc.edu/myofilament-conference/#meeting-overview, http://www.cardioascona.ch/resources/FinalProgram_21.04.2018.pdf, https://www.ifom.eu/events/2019-cell-mech/, http://cardiac-mec.org/cardiac-mec//programme/lectures.html), invitation to chair a session (https://www.emc2019.com/what). Led to feature as “Cell Scientist to Watch” (https://jcs.biologists.org/content/133/15/jcs251595?cpetoc), invited reviews in Dev Cell (PMID:31211988) and BBA MRC (PMID:30742931). This was highlighted by the BHF for their magazine 'Heart Matters' in an article and with an animated video (https://www.bhf.org.uk/informationsupport/heart-matters-magazine/research/nanotechnology).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -