A bioengineered three-dimensional cell culture platform integrated with microfluidics to address antimicrobial resistance in tuberculosis
- Submitting institution
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University of Southampton
- Unit of assessment
- 12 - Engineering
- Output identifier
- 34296360
- Type
- D - Journal article
- DOI
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10.1128/mBio.02073-16
- Title of journal
- mBio
- Article number
- e02073-16
- First page
- -
- Volume
- 8
- Issue
- 1
- ISSN
- 2150-7511
- Open access status
- Compliant
- Month of publication
- February
- Year of publication
- 2017
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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6
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This is the first system using a microfluidic 3D culture platform to enable tackling antimicrobial resistance (AMR) in tuberculosis. We have combined bioengineering, genetically modified bacteria, longitudinal readouts, and fluidics to develop a transformative platform to address the drug development bottleneck. It laid the foundation for further systematic studies supported by an MRC grant (£345k). The work has also been extended to addressing AMR challenges in a one-health context by a large UK-India consortium (£3 million) with £307k coming to Southampton from ESRC.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -