Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells
- Submitting institution
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Abertay University
- Unit of assessment
- 12 - Engineering
- Output identifier
- 15636087
- Type
- D - Journal article
- DOI
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10.1016/j.jbiotec.2014.09.027
- Title of journal
- Journal of Biotechnology
- Article number
- -
- First page
- 12
- Volume
- 202
- Issue
- -
- ISSN
- 0168-1656
- Open access status
- Out of scope for open access requirements
- Month of publication
- November
- Year of publication
- 2014
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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5
- Research group(s)
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D - Modelling & Simulation
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- We identified mechanisms of action for reactive oxygen species regulation in multiple cell lines through integrated experimental and theoretical modelling. We analysed the role of the NRF2 pathway in regulation of oxidation reduction. Significantly the work has been used as the basis of new (2019) work led by one of the leaders in the field (K Janes) and presented in Science Signalling, part of the Science journal family. In their study into oxidative stress-dependent activity in the NRF2–p53 signalling network in breast cancer our computational model is used as the basis of the NRF2 modelling undertaken by Janes’s group.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
