Computational design of nucleic acid feedback control circuits
- Submitting institution
-
The University of Warwick
- Unit of assessment
- 12 - Engineering
- Output identifier
- 9182
- Type
- D - Journal article
- DOI
-
10.1021/sb400169s
- Title of journal
- ACS Synthetic Biology
- Article number
- -
- First page
- 600
- Volume
- 3
- Issue
- 8
- ISSN
- 2161-5063
- Open access status
- Out of scope for open access requirements
- Month of publication
- July
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper proposes the first software platform for the design and simulation of Linear Time Invariant (LTI) systems using DNA/RNA/enzymes. This research has had significant uptake by industry via: i) a toolbox for the Microsoft Research Visual DSD software environment; and ii) a code for myTXTL product (see http://arborbiosci.com/products/mytxtl-toolbox-2-0-plasmid-collection/) of Arbor Biosciences, now acquired by Chiral Technologies. Awards and Funding directly resulting from this research include: a 4-year Microsoft Research PhD Fellowship (Andrew.Phillips@microsoft.com); and two Dstl Phase 1 grants - DSTLX1000104113 (£79,800) and ACC101854 (£78,800) - to exploit the platform for optimisation of novel hydrogels.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -