A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches
- Submitting institution
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University of Hertfordshire
- Unit of assessment
- 12 - Engineering
- Output identifier
- 22632920
- Type
- D - Journal article
- DOI
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10.1016/j.ijpharm.2020.119782
- Title of journal
- International Journal of Pharmaceutics
- Article number
- 119782
- First page
- -
- Volume
- 588
- Issue
- -
- ISSN
- 0378-5173
- Open access status
- Compliant
- Month of publication
- August
- Year of publication
- 2020
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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12
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Annually, 15 million babies in the US suffer from preterm birth (PB) costing $25 billion. This research reports a development of a novel biodegradable/biocompatible PLA fibrous-patch system loaded with progesterone, a potent drug. This new patch system acted as an effective drug delivery carrier with Intravaginally in vivo tests using a rat model presented. This new patch system gave increased productive yield and better medical performance than those of standard electro-spanned patches. The research show the PGP patch system could have impact as a successful treatment strategy for preventing PB with High bioactivity and reduced dosage quantity and frequency.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -