Fam49/CYRI interacts with Rac1 and locally suppresses protrusions
- Submitting institution
-
Coventry University
- Unit of assessment
- 3 - Allied Health Professions, Dentistry, Nursing and Pharmacy
- Output identifier
- 21517418
- Type
- D - Journal article
- DOI
-
10.1038/s41556-018-0198-9
- Title of journal
- Nature Cell Biology
- Article number
- -
- First page
- 1159
- Volume
- 20
- Issue
- -
- ISSN
- 1465-7392
- Open access status
- Exception within 3 months of publication
- Month of publication
- September
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
20
- Research group(s)
-
-
- Citation count
- 12
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- In this paper, I performed experiments: specifically, I labelled cells bioorthoganally with C14:0-azide, immunoprecipitated GFP-tagged proteins on magnetic beads and used click chemistry-based detection methods to demonstrate that CYRI-B is myristoylated. Furthermore, I showed that mutating the glycine at position 2 to alanine abolished the CLICK signal to a level similar to the GFP negative control, therefore also identifying the site of CYRI-B myristoylation. I was also involved in drafting the output, along with critiquing all the figures and data presented.
- Non-English
- No
- English abstract
- -