In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation
- Submitting institution
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University of Dundee
- Unit of assessment
- 12 - Engineering
- Output identifier
- 28167599
- Type
- D - Journal article
- DOI
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10.1016/j.jconrel.2014.10.022
- Title of journal
- Journal of Controlled Release: Official Journal of the Controlled Release Society, and of the Japan Society of Drug Delivery System
- Article number
- -
- First page
- 355
- Volume
- 196
- Issue
- -
- ISSN
- 0168-3659
- Open access status
- Out of scope for open access requirements
- Month of publication
- December
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- 5 - Biological Sciences
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
6
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper has succeeded in influencing protocol developments for topical delivery of siRNA. For example, the active species in our patented [GB 1222922.5] penetration enhancing modification was incorporated in a recent investigation to identify the underlying molecular mechanism of action by a prominent Korean group [Journal of Investigative Dermatology (2019), Volume 139 p1098] and our developed protocol itself has been successfully modified as the basis for another recent study in the journal, Experimental & Molecular Medicine (2018) 50, e446; doi:10.1038/emm.2017.272]. Overall, there is wider appreciation of the scientific advantages this particular technique and active ingredient delivers across dermatology.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -